CureVac will present, among other data, extended preliminary immunogenicity results from Part A of the dose escalation phase of its ongoing Phase 1 CVGBM cancer vaccine study in patients with resected glioblastoma. The presentation will expand on safety, tolerability and immunogenicity results of the CVGBM trial presented last month at the European Society for Medical Oncology (ESMO) Congress, which demonstrated treatment with CVGBM monotherapy successfully induced cancer antigen-specific T-cell responses in 77% of evaluable patients, 84% of which were de novo.

Details on all poster presentations are below:

Abstract:  697

Title: Preliminary immunogenicity results from the dose escalation phase of a first-in-human study of the mRNA-based cancer vaccine CVGBM in patients with newly diagnosed MGMT-unmethylated glioblastoma
Session type: Poster Presentation
Date: November 8
Presenting Author: Sven Koch, Ph.D., Director Immuno-Monitoring, CureVac SE

Abstract:  380

Title: mRNA vaccination enhances TCRtg T cell therapy efficacy in solid tumors
Session type: Poster Presentation
Date: November 9
Presenting Author: Dr. Johannes Lutz, Director Pre-Clinical Development, CureVac SE

Abstract:  370

Title: Identification and validation of a T cell receptor recognizing shared HLA-A02:01 presented epitope from TP53 frameshift
Session type: Poster Presentation
Date: November 9
Presenting Author: Katka Franke, Ph.D., Pharm.D., Director Oncology Antigen Discovery and Validation, CureVac Netherlands B.V.